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8:06 During fasting or starvation ; gluconeogenesis takes place in the majority of tissues through 2 main pathways : (1) Oxidation reaction of lactate to pyruvate . (2) Transamination reactions of amino acids released from protein breakdown to their corresponding alpha keto acids . Pyruvate - an alpha keto acid - generated either by oxidation of lactate or transamination of alanine amino acid undergoes a key step in the gluconeogenesis pathway which involves its CARBOXYLATION to oxaloacetate ; a process catalyzed by the enzyme PYRUVATE CARBOXYLASE . Pyruvate carboxylase enzyme is highly regulated by ATP levels & ALLOSTERICALLY ACTIVATED by acetyl coA levels . So lack of ATP & acetyl coA will down regulate its activity . In case of medium chain acyl coA dehydrogenase (MCAD) deficiency , the ATP & acetyl coA production during fasting , starvation & illness is markedly reduced . As a result the generation of oxaloacetate from pyruvate & the subsequent production of glucose from oxaloactate down that gluconeogenic pathway will be markedly reduced ; leading to HYPOGLYCEMIA ! 2 points are worth mentioning : 1. Medium chain & short chain fatty acids do NOT utilize the carnitine shuttle across the mitochondrial membranes to reach the mitochondrial matrix ; only the long chain fatty acids do . 2. In aerobic conditions ; for every single acetyl coA molecule produced from glucose through glycolysis & pyruvate oxidative decarboxylation an energy equivalent of 6 ATP molecules is generated ; while in case of beta oxidation of fatty acids only 4 ATP molecules are generated for every single acetyl coA molecule with an overall subtraction of 2 high energy bonds consumed during the initial step of activation of the fatty acid to acyl coA . So glucose is a way energy efficient compared to fatty acids & less amount of oxygen is required to generate the vital energy needs of the body through glucose compared to fatty acids requiring higher oxygen consumption ! In a way or another ; that might explain the pathognomonic sign of ketosis , Kaussmaul sign of rapid deep respiration OR hyperventilation when beta oxidation of fatty acids takes the upper hand . Lord knows best !

What causes gastritis: Everything

thank you my goat. excellant! veerrrrry good!!!!🧎🏻‍♂may allah bless you.

Glucos to Sorbitol using Aldose Reductase Enzyme, do we need to heat them up at 140C?

I have been suffering from gastritis for years and Planet Ayurveda's herbal remedies have been a game changer for my digestive health.

ANOTHER FAKE NEWS

Thank you sir.

Dr this is the best video have gastritis beause i had hypori thank you so so much this us a wealth of information

Where are you sir…you are legend in this field…….7 yrs still hearing your classes..Absolute legend

Thank you for this information i have been suffering two yrs now

nurse anaesthesia program here. thank you so much for this short, clear explanation.

inicet is makin me go insane

Thankyou sir this is so helpful

Amazing explanation sir.Plz make more animated lectures like this. Respect from Pakistan

So if we stop feeding cancer cells with sugar it will die is it ??? Processed sugar or any kind of sugar ??

Very useful lecture sir Conceptual lecture sir Thanks sir

yed zinkut

I tested negative from Herpes after I used herbs from Dr Okosun on you tube. I was a carrier for 7 years and has been negative after using his herbs for 3 years today.

This is the best explanation for gastritis i have heard so far. Thank you so much doctor.

Did you say pain on feet and hands is one of the signs of gastritis? Can you explain a little bit more? Thank you.

Sir why vldl is called pre beta,it is after beta so it should be post beta right??

Thank you Doctor . it helped me a lot

Sir please share its treatment

7 days treatment of gastritis is Amoxicillin 500mg 3 times a day levofloxacin 500mg 1 times and pantaprazole 3 times and metrogyl 200 mg 3 times a day.

Excellent sir 🙏

Thanks a lot Sir.. I was having difficulty to grasp this enzyme having 2 parts.. you have made it crystal clear in my mind now... Thank You so much Sir

Does the AA pattern represents AA genotype

❤thanku sir❤

اردو نی آتی

Super sir

Which time is best to expose sun light to get vitamin D? My vitamin d result is 7.08 ng/mL.

Cool but does Chronic gastritis can be completly healed, or it is just remission?

🏃 'promo sm'

KIRKLAND

You are class apart

I've had it since I was 7. I'm 34 now 🤡 No helicobacter infection, I don't know where it comes from. Currently it's so bad I suspect cancer.

Sir, please share the link for protein content in pulses and legumes .. Also it would be helpfull if you can share how do you plan IF with vegeterian diet and completing your protein goals for the day.

Very informative video Prakash sir.

I can’t believe other people are talking about this. I was diagnosed with CPT II around 17 years old and now that I’m older age 38 it seems to be getting worse. I get random swelling and pain in my foot and my elbow and sometimes my legs. And yes, it can be unbearable to a point that I have to use crutches to get around. Not many people know about this because it’s so rare. Any tips you guys may have is greatly appreciated.

Thank u soo much it was too helpfull

God bless you sir, have been on these thing for months but I get it better now!

Thank u so much i understand it better now

Superb sir

A very skilled teacher ...indeed

Nice lecture sir..

This can make people dizzy because low blood sugar, Is better to study how over hydration, can Increase body weight via Osmosis is safer and reduce hunger

Captions

How much water should we drink and when?

Thank you so much sir, it's a great lecture.... gave me understanding of lot if things .....

Amazingly explained sir